Gene information
Official symbol PTGS1
Official full name prostaglandin-endoperoxide synthase 1
Gene type protein-coding gene
Chromosome9q33.2
Alias symbolCOX1; PGHS-1; PTGHS
Resources
Entrez Gene 5742
HGNC HGNC:9604
Ensembl ENSG00000095303
Vega OTTHUMG00000020605
UCSC uc004bmg.3
GO terms: 39 records
GO Description Category LogP Number of genes Detail
GO:0001516 prostaglandin biosynthetic process GO Biological Processes -6.90547690 6 More
GO:0001676 long-chain fatty acid metabolic process GO Biological Processes -13.6883394 17 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0004601 peroxidase activity GO Molecular Functions -5.52369866 7 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006636 unsaturated fatty acid biosynthetic process GO Biological Processes -5.20458879 6 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006692 prostanoid metabolic process GO Biological Processes -9.18831190 9 More
GO:0006693 prostaglandin metabolic process GO Biological Processes -9.18831190 9 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016209 antioxidant activity GO Molecular Functions -11.3593886 22 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO Molecular Functions -5.30702712 7 More
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO Molecular Functions -3.69512980 4 More
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO Molecular Functions -3.76678874 4 More
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO Molecular Functions -11.3284001 18 More
GO:0019369 arachidonic acid metabolic process GO Biological Processes -15.7454969 15 More
GO:0019371 cyclooxygenase pathway GO Biological Processes -5.63167427 4 More
GO:0020037 heme binding GO Molecular Functions -15.4577568 20 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046456 icosanoid biosynthetic process GO Biological Processes -13.7551761 13 More
GO:0046457 prostanoid biosynthetic process GO Biological Processes -6.90547690 6 More
GO:0046906 tetrapyrrole binding GO Molecular Functions -14.8570803 20 More
GO:0051213 dioxygenase activity GO Molecular Functions -2.29650667 5 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0097237 cellular response to toxic substance GO Biological Processes -13.7473733 28 More
GO:0098754 detoxification GO Biological Processes -12.4136065 17 More
GO:0098869 cellular oxidant detoxification GO Biological Processes -12.6410846 24 More
GO:0120254 olefinic compound metabolic process GO Biological Processes -12.8805599 18 More
GO:1990748 cellular detoxification GO Biological Processes -12.8821364 16 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa00590 Arachidonic acid metabolism KEGG Pathway -11.1782370 12 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa04726 Serotonergic synapse KEGG Pathway -8.91693578 13 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
Drug-Gene interaction
view
Related drugs: 61 records
Drug name Interaction type Source PMID View
(+)-epicatechin TTD view
acetaminophen inhibitor DTCTdgClinicalTrialChemblInteractionsTEND 178849741175235219053765 view
aminosalicylate potassium inhibitor ChemblInteractions view
aminosalicylate sodium inhibitor ChemblInteractions view
aspirin inhibitor DTCChemblInteractionsTENDPharmGKB 20938371236513591649348622940005 view
balsalazide inhibitor TdgClinicalTrialTTD 1295041511752352171392841701642319743890 view
balsalazide disodium inhibitor ChemblInteractions view
bismuth subsalicylate inhibitor ChemblInteractions view
bromfenac inhibitor TdgClinicalTrialTENDTTD 1684654611752352 view
bromfenac sodium inhibitor ChemblInteractions view
clopidogrel PharmGKB 22940005 view
curcumin DTCTTD 24920381 view
curcumin pyrazole DTC 24920381 view
dersalazine TdgClinicalTrial view
diclofenac inhibitor TdgClinicalTrialChemblInteractionsTEND 127135961296636612852704117523521241487412534640 view
diclofenac epolamine inhibitor ChemblInteractions view
diclofenac potassium inhibitor ChemblInteractions view
diclofenac sodium inhibitor ChemblInteractions view
diflunisal inhibitor TdgClinicalTrialChemblInteractionsTEND 87377481285248315755648 view
e163 DTC 10075763 view
etodolac inhibitor TdgClinicalTrialTEND 85661099146894123580531647342415198222 view
fenbufen TTD view
fenoprofen inhibitor TdgClinicalTrialTEND 17050798 view
fenoprofen calcium inhibitor ChemblInteractions view
flurbiprofen inhibitor ChemblInteractionsTEND 11811354103580651077301112392782175621701271184419066416 view
flurbiprofen sodium inhibitor ChemblInteractions view
ginger NCI 14693173 view
hydrochlorothiazide NCI 11703585 view
ibuprofen inhibitor DTCTdgClinicalTrialChemblInteractionsTENDPharmGKB 235362071498782323651359255026151474126515575422145925491285270411752352 view
ibuprofen lysine inhibitor ChemblInteractions view
ibuprofen sodium inhibitor ChemblInteractions view
imrecoxib TTD view
indomethacin inhibitor DTCChemblInteractionsTEND 158918862365135915700751157434042068459815887968228180411038105715831902 view
ketoprofen inhibitor TdgClinicalTrialChemblInteractionsTEND 1181135414987823145137181092908915476667 view
ketorolac inhibitor TdgClinicalTrialTEND 1169525516262557102205091627761310422661 view
ketorolac tromethamine inhibitor ChemblInteractions view
latanoprost PharmGKB 25339146 view
meclofenamate sodium inhibitor ChemblInteractions view
mefenamic acid inhibitor ChemblInteractions 9626023113162487832763162239589773153 view
mesalamine inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 1295041511752352 view
nabumetone inhibitor TdgClinicalTrialTEND 755470894814681646968011525777 view
naproxcinod inhibitor TdgClinicalTrialChemblInteractions view
naproxen inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 1754179630247840 view
naproxen etemesil inhibitor ChemblInteractions view
naproxen sodium inhibitor ChemblInteractions view
nepafenac inhibitor TdgClinicalTrialChemblInteractionsTEND 10850857 view
olsalazine sodium inhibitor ChemblInteractions view
oxaprozin inhibitor ChemblInteractions 193385799831331153245301995241617024689 view
oxaprozin potassium inhibitor ChemblInteractions view
oxyphenbutazone inhibitor ChemblInteractions view
phenylbutazone inhibitor ChemblInteractions 155639281593962219849999 view
piroxicam inhibitor ChemblInteractionsTENDTTD 1195215511785774111531631546483210381057 view
salsalate inhibitor TdgClinicalTrialTENDTTD 1680855104528681175235215242723 view
sulfasalazine inhibitor TdgClinicalTrialChemblInteractions 12950415 view
sulindac inhibitor TdgClinicalTrialChemblInteractionsTEND 1037282612512695106268101258621110484067 view
suprofen inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 118859591175235217477341103774558652509 view
tenoxicam inhibitor TdgClinicalTrialTEND 17017983115633329175172915241215943176 view
tolmetin inhibitor TdgClinicalTrialTEND 1461355010465690925395416182428 view
tolmetin sodium inhibitor ChemblInteractions view
ursolic acid DTC 9784154 view
vb-201 TdgClinicalTrial view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_000962.4:c.-842A>G genomics clopidogrel[treatment (pharmacotherapy)] acute myocardial infarction Ulehlova J et al. Genet Test Mol Biomarkers. 2014
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